Detalhe da pesquisa
1.
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Mol Cell
; 83(15): 2753-2767.e10, 2023 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37478846
2.
Design principles for cyclin K molecular glue degraders.
Nat Chem Biol
; 20(1): 93-102, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37679459
3.
Small-molecule-induced polymerization triggers degradation of BCL6.
Nature
; 588(7836): 164-168, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33208943
4.
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Nature
; 585(7824): 293-297, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32494016
5.
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Blood
; 142(24): 2079-2091, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37595362
6.
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Blood
; 139(4): 538-553, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34624079
7.
A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common ß chain (CSF2RB) protein stability.
J Biol Chem
; 298(10): 102484, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36108743
8.
Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry.
J Am Chem Soc
; 145(40): 21937-21944, 2023 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37767920
9.
Anti-SARS-CoV-2 activity of targeted kinase inhibitors: Repurposing clinically available drugs for COVID-19 therapy.
J Med Virol
; 95(1): e28157, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36117402
10.
Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs.
Blood
; 134(2): 160-170, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31043423
11.
TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.
Blood
; 131(25): 2789-2802, 2018 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653964
12.
HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies.
Blood
; 130(14): 1628-1638, 2017 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28830887
13.
Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival.
Proc Natl Acad Sci U S A
; 113(20): 5688-93, 2016 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27155012
14.
MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia.
Br J Haematol
; 179(3): 421-429, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28771672
15.
Recurrent CDKN1B (p27) mutations in hairy cell leukemia.
Blood
; 126(8): 1005-8, 2015 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26065650
16.
Genome-scale RNAi profiling of cell division in human tissue culture cells.
Nat Cell Biol
; 9(12): 1401-12, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994010
17.
Genetic retargeting of E3 ligases to enhance CAR T cell therapy.
Cell Chem Biol
; 31(2): 338-348.e5, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37989314
18.
Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division.
EMBO J
; 28(10): 1453-65, 2009 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19387489
19.
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.
PLoS Biol
; 8(6): e1000408, 2010 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20613862
20.
The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein.
iScience
; 26(5): 106601, 2023 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37095859